Steroid ointment for dermatitis

The corticosteroids are a class of compounds comprising steroid hormones secreted by the adrenal cortex and their synthetic analogs. In pharmacologic doses, corticosteroids are used primarily for their anti-inflammatory and/or immunosuppressive effects. Topical corticosteroids such as clobetasol propionate are effective in the treatment of corticosteroid-responsive dermatoses primarily because of their anti-inflammatory, antipruritic, and vasoconstrictive actions. However, while the physiologic , pharmacologic, and clinical effects of the corticosteroids are well known, the exact mechanisms of their actions in each disease are uncertain.

You can buy some topical corticosteroids "over-the-counter" without a prescription. For example, for dermatitis, you can buy the steroid cream called hydrocortisone 1% from your pharmacy. Do not apply this to your face unless your doctor has told you to do so. This is because it may trigger a skin condition affecting the face ( acne or rosacea. ) Long-term use may also damage the skin. On your face this would be more noticeable than the rest of your body. So usually only weak steroids are used on the face. Those which are suitable are prescription-only.

An Alternative Treatment

Decreased tear meniscus in dry eye.
As an alternative to steroids—or as an adjunctive therapy—topical cyclosporine can also be used to control inflammation in dry eye disease. While cyclosporine does not demonstrate the rapid anti-inflammatory effect of steroids, it carries fewer risks and is safe for long-term use.
Because of their complementary efficacy and safety profiles, many practitioners often begin dry eye treatment by prescribing both topical steroids and cyclosporine. Following the recommendation of the Asclepius Panel, the use of combination therapy is instituted with the topical corticosteroid, Lotemax (loteprednol etabonate ophthalmic suspension %, Bausch + Lomb) and Restasis (cyclosporine ophthalmic emulsion %, Allergan). 24 The Asclepius Panel recommends practitioners begin early treatment with an anti-inflammatory agent (such as Lotemax) four times a day to improve symptoms and to prevent disease progression. After two weeks, the frequency of the corticosteroid is reduced to twice daily and supplemented with Restasis twice a day. Treatment with loteprednol was stopped after day 60, while cyclosporine treatment is continued.

An ointment of the present invention as prepared in Example 1 was tested in a bilateral paired psoriasis study using a conventional betamethasone 17,21-dipropionate ointment consisting of mg/g betamethasone 17,21-dipropionate, mg/g mineral oil and mg/g white petrolatum. Results of the bilateral paired comparison study [P values based on two-tailed sign test] indicate the ointment of Example 1 to be significantly (p ≤ ) more effective than the conventional ointment in the treatment of patients with chronic, stubborn psoriasis, based on the following results:

Steroid ointment for dermatitis

steroid ointment for dermatitis

An ointment of the present invention as prepared in Example 1 was tested in a bilateral paired psoriasis study using a conventional betamethasone 17,21-dipropionate ointment consisting of mg/g betamethasone 17,21-dipropionate, mg/g mineral oil and mg/g white petrolatum. Results of the bilateral paired comparison study [P values based on two-tailed sign test] indicate the ointment of Example 1 to be significantly (p ≤ ) more effective than the conventional ointment in the treatment of patients with chronic, stubborn psoriasis, based on the following results:

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