Corticosteroid use can cause a variety of psychiatric syndromes, including mania, psychosis, depression, and delirium. A meta-analysis reports severe psychotic reactions in % of patients taking corticosteroids and mild-to-moderate reactions in 28% of patients. 1 Hypomania, mania, and psychosis are the most common psychiatric reactions to acute corticosteroid therapy. 2 This article reviews case reports and open-label trials of antipsychotics, mood stabilizers, and anticonvulsants to treat corticosteroid-induced mania and psychosis and outlines treatment options.
Lithium is well known to cause various side-effects, including renal dysfunction and symptoms of lithium intoxication such as convulsions. While taking lithium, our patient did not show any of signs or symptoms of liver or kidney dysfunction or lithium intoxication. Serum lithium levels were – mEq/l (normal – mEq/l). In BMT settings, immunosuppressive agents have a nephrotoxic effect and may cause renal dysfunction. It is necessary to monitor the serum lithium level and to evaluate any clinical signs or symptoms suggesting lithium intoxication. Lithium carbonate can be used for cancer patients by monitoring laboratory data many times. In many previous reports, lithium treatment was performed safely for steroid-induced depression in systemic lupus erythematosus patients who often have a risk of renal dysfunction ( 10 , 12 ).