A retinal detachment occurs when the retina is pulled away from its normal position in the back of the eye. The retina sends visual images to the brain through the optic nerve . When detachment occurs, vision is blurred. A detached retina is a very serious problem that almost always causes blindness unless it is can be from tears or holes in the retina, or from fluid accumulation between the retina and underlying layers. When there is a tear of the retina, liquid from the vitreous may pass through the tear, and detach the retina. As the fluid accumulates, the retinal detachment becomes larger. Detached areas of the retina lose their vision. Most people notice floaters and flashes before the retina detaches. As the detachment occurs, a gradually enlarging dark area may be seen. Anyone with flashes or the sudden onset of a new floater (or floaters) should be examined promptly by an ophthalmologist . The ophthalmologist will search carefully for retinal tears.
As a glucocorticoid , the lipophilic structure of prednisolone allows for easy passage through the cell membrane where it then binds to its respective glucocorticoid receptor (GCR) located in the cytoplasm. Upon binding, formation of the GC/GCR complex causes dissociation of chaperone proteins from the glucocorticoid receptor enabling the GC/GCR complex to translocate inside the nucleus. This process occurs within 20 minutes of binding. Once inside the nucleus, the homodimer GC/GCR complex binds to specific DNA binding-sites known as glucocorticoid response elements (GREs) resulting in gene expression or inhibition. Complex binding to positive GREs leads to synthesis of anti-inflammatory proteins while binding to negative GREs block the transcription of inflammatory genes.