Man this stuff is great. Used to get it from oxide but they shut down. Yes it does work for spot reduction. This practice is described as "meso therapy". It's been said that by directly injecting the hormone into trouble areas does indeed yield noticeable results. I've read that the fat is disolved into lipids in the bloodstream and made available for energy/burning, providing you're exercising. I also heard that cardio isn't mandatory for this to work. I don't know but I'd say if there are lipids floating around that they'd be re=stored if not used up as energy. Anyway hope this helps. BTW, only place I've seen it is regenxxl. Unfortunately out of stock.