Corticosteroid therapy effects

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The most commonly reported side effects were: oral thrush , nausea , headache , and pain in the pharynx or larynx . More rarely reported side effects (occurring in <1% of patients during the clinical trial) include: tachycardia , palpitations , dry mouth , allergic reaction ( bronchospasm , dermatitis , hives ), pharyngitis , muscle spasms , tremor , dizziness , insomnia , nervousness , and hypertension . Patients experiencing an allergic reaction or increase in difficulty breathing while using this medication should immediately discontinue its use and contact their physician. [4]

Intralesional fluorouracil (50 mg per mL, two to three times per week) appears to shrink keloids safely while avoiding the tissue atrophy and telangiectasia that may occur with repeated corticosteroid injections. 30 Combining fluorouracil with corticosteroid injections and pulsed dye laser produced superior results more rapidly than corticosteroid injections alone or corticosteroids with fluorouracil. 13 Good to excellent responses at 12 weeks as rated by a blinded observer were 15 percent for triamcinolone acetonide, 40 percent for triamcinolone plus fluorouracil, and 70 percent for all three modalities (all significant). Combining corticosteroids and fluorouracil diminished the adverse effects of corticosteroids. Rare skin complications of fluorouracil may include hyperpigmentation and wound ulceration. No systemic adverse effects (., anemia, leucopenia, thrombocytopenia) occurred in this study.

REFERENCES:
Committee Opinion Committee on Obstetric Practice Number 210, October 1998 Antenatal Corticosteroid Therapy for Fetal Maturation
2. NIH Consensus Statement Effect of Corticosteroids for Fetal Maturation on Perinatal Outcomes1994 Feb 28-Mar 2;12(2):1-24
3. Morrison JC, Whybrew WD, Bucovaz ET, Schneider JM. Injection of corticosteroids into mother to prevent neonatal respiratory distress syndrome. Am J Obstet Gynecol 131:358,1978. MEDLINE
4. Morrison JC, Schneider JM, Whybrew WD, Bucovaz ET. Effect of corticosteroids and Fetomaternal disorders on the L:S ratio. Obstet Gynecol 56:583, 1980 MEDLINE Please review the Disclaimer before using this site. Copyright © 2000-2008 by Focus Information Technology.
All rights reserved.
Created: 11/30/2002
Update: 11/30/2002
Update: 4/15/2008

Corticosteroid therapy effects

corticosteroid therapy effects

REFERENCES:
Committee Opinion Committee on Obstetric Practice Number 210, October 1998 Antenatal Corticosteroid Therapy for Fetal Maturation
2. NIH Consensus Statement Effect of Corticosteroids for Fetal Maturation on Perinatal Outcomes1994 Feb 28-Mar 2;12(2):1-24
3. Morrison JC, Whybrew WD, Bucovaz ET, Schneider JM. Injection of corticosteroids into mother to prevent neonatal respiratory distress syndrome. Am J Obstet Gynecol 131:358,1978. MEDLINE
4. Morrison JC, Schneider JM, Whybrew WD, Bucovaz ET. Effect of corticosteroids and Fetomaternal disorders on the L:S ratio. Obstet Gynecol 56:583, 1980 MEDLINE Please review the Disclaimer before using this site. Copyright © 2000-2008 by Focus Information Technology.
All rights reserved.
Created: 11/30/2002
Update: 11/30/2002
Update: 4/15/2008

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