While knee cartilage did not seem to regenerate for patients, the fact that the arthritis did not worsen may be significant. Evidence suggests that an average of 4 to 6% of cartilage disappears each year in arthritic joints. 22,23 PRP Does Not Work for Everyone Not all clinical studies provide evidence that PRP alleviates osteoarthritis symptoms. In several clinical studies PRP injections were no better than a placebo treatment. Even in studies that do provide evidence that PRP works, not all patients benefit. See Is Stem Cell Therapy for Arthritis Safe and Effective?
Before trying Synvisc-One, tell your doctor if you have had an allergic reaction, such as swelling of the face, tongue or throat, respiratory difficulty, rash, itching or hives to SYNVISC or any hyaluronan-based products. Allergic reactions, some which can be potentially severe, have been reported during the use of Synvisc-One. Should not be used in patients with an infected knee joint, skin disease or infection around the area where the injection will be given, and should be used with caution when there is swelling of the legs due to problems with venous stasis or lymphatic drainage.
Arthritis of the knee is caused by inflammation and damage of one or more compartments in the knee joint. Arthritis can be divided into different forms depending on the cause; where osteoarthritis is caused by progressive wearing away of the cartilage that covers the ends of your bones, rheumatoid arthritis is a chronic autoimmune disorder that targets the lining of the joints. Other types of arthritis can be caused by infections, underlying disease (such as systemic lupus erythematosus), or accumulation of uric acid crystals. If you want to know whether you have arthritis of the knee, learn to recognize the signs and symptoms most commonly associated with the condition.