11 beta-hydroxysteroid dehydrogenase type 1 and obesity

Cortisol , a glucocorticoid, binds the glucocorticoid receptor. However, because of its molecular similarity to aldosterone it is also capable of binding the mineralcorticoid receptor. Both aldosterone and cortisol have a similar affinity for the mineralocorticoid receptor; however, there is vastly more cortisol in circulation than aldosterone. To prevent over-stimulation of the mineralocorticoid receptor by cortisol, HSD-11β converts the biologically active cortisol to the inactive cortisone, which can no longer bind to the mineralocorticoid receptor. 11β-HSD co-localizes with intracellular adrenal steroid receptors. Licorice , which contains glycyrrhetinic acid , or enoxolone can inhibit 11β-HSD and lead to a mineralocorticoid excess syndrome .

11 beta-hydroxysteroid dehydrogenase type 1 and obesity

11 beta-hydroxysteroid dehydrogenase type 1 and obesity

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11 beta-hydroxysteroid dehydrogenase type 1 and obesity11 beta-hydroxysteroid dehydrogenase type 1 and obesity11 beta-hydroxysteroid dehydrogenase type 1 and obesity11 beta-hydroxysteroid dehydrogenase type 1 and obesity11 beta-hydroxysteroid dehydrogenase type 1 and obesity